Drug Profile


Alternative Names: Batenac®; Befral®; Cerate®; Mibefradil dihydrochloride; Posicor®; Quota®; RO 40-5967; Taxben®

Latest Information Update: 10 Apr 2017

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At a glance

  • Originator Roche
  • Developer Cavion
  • Class Antihypertensives; Benzimidazoles; Ischaemic heart disorder therapies; Small molecules; Tetrahydronaphthalenes; Vasodilators
  • Mechanism of Action Cell division modulators; DNA repair inhibitors; T type calcium channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Ovarian cancer; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Glioblastoma; Glioma
  • Preclinical Ovarian cancer; Pancreatic cancer; Solid tumours
  • Market Withdrawal Angina pectoris; Hypertension
  • Discontinued Arrhythmias; Heart failure

Most Recent Events

  • 31 Mar 2017 Cavion completes a phase-I trial in Glioblastoma (Second-line therapy or greater, Recurrent, Late-stage disease) in USA (PO) (NCT02202993)
  • 26 Sep 2016 Cavion plans a clinical trial for Brain cancer (In newly diagnosed)
  • 26 Sep 2016 Cavion plans a phase I trial for Glioblastoma (Newly diagnosed)
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