Drug Profile


Alternative Names: Avanza; Azamianserin; ME-2040; Mepirzapin; Norset; ORG-3770; Promyrtil; Reflex; REFLEX Org3770; Remergil; Remergon; Remeron; RemeronSolTab; Rexer; Zispin

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Organon
  • Developer Meiji Seika Pharma; Merck & Co
  • Class Dibenzazepines; Tetracyclic antidepressants
  • Mechanism of Action Alpha 2 adrenergic receptor antagonists; Serotonin 2 receptor antagonists; Serotonin 3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Major depressive disorder
  • Phase II Fibromyalgia

Most Recent Events

  • 01 Oct 2015 Phase-II development is ongoing for Fibromyalgia in Japan (PO) (Meiji Seika Pharma pipeline, October 2015)
  • 31 Oct 2014 Meiji Seika Pharma completes a phase II trial in Fibromyalgia in Japan (JapicCTI-122005)
  • 31 Mar 2013 Mirtazapine is still in phase II trials for Fibromyalgia in Japan
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