Drug Profile


Alternative Names: Ethiofos; Ethyol; Gammaphos; NSC 296961; WR 2721; YM 08310

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Southern Research Institute
  • Developer MedImmune Oncology
  • Class Chemoprotectants; Organothiophosphorus compounds; Small molecules
  • Mechanism of Action Oxygen radical scavengers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Radiation injuries; Chemotherapy-induced damage; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chemotherapy-induced damage; Radiation injuries
  • Discontinued Myelodysplastic syndromes

Most Recent Events

  • 10 May 2016 Clinigen and Cumberland Pharmaceuticals enter into an agreement for commercialisation of amifostine in USA
  • 20 Aug 2014 Clinigen acquires global right to amifostine from AstraZeneca (MedImmune)
  • 29 Jan 2008 Discontinued - Clinical-Phase-Unknown for Radiation injuries (Prevention) in USA (SC)
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