Paclitaxel - Bristol-Myers Squibb

Drug Profile

Paclitaxel - Bristol-Myers Squibb

Alternative Names: BMS-181339; BMY 45622; NSC-673089; Taxol

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator National Institutes of Health (USA)
  • Developer Bristol-Myers Squibb; University of Washington
  • Class Antineoplastics; Diterpenes; Paclitaxels; Small molecules; Taxanes
  • Mechanism of Action Mitosis inhibitors; Proto-oncogene protein c-bcl-2 inhibitors; Tubulin polymerisation promoters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; Kaposi's sarcoma; Non-small cell lung cancer; Ovarian cancer
  • Phase II Head and neck cancer
  • Discontinued Bladder cancer; Cancer metastases; Cervical cancer; Endometrial cancer; Leukaemia; Lung cancer; Mesothelioma; Multiple myeloma; Non-Hodgkin's lymphoma; Pleural effusion; Prostate cancer; Sarcoma; Small cell lung cancer; Testicular cancer

Most Recent Events

  • 08 May 2017 Bristol-Myers Squibb terminates a phase I/II trial as the sponsor withdrew the study in Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (IV) (NCT00041470)
  • 30 May 2013 Biomarkers information updated
  • 17 Mar 2005 Registered as adjuvant treatment for early stage node-positive breast cancer in European Union under the mutual recognition procedure; the Netherlands acted as the reference member state (IV-infusion)
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