Decitabine

Drug Profile

Decitabine

Alternative Names: 127716; 2'-deoxy-5-azacytidine; 5-aza-2'-deoxycytidine; DAC; Dacogen; Decitabine mesylate; Deoxycytidine; Dezocitidine; E 7373; NSC-127716

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Indiana University; SuperGen
  • Developer Eisai Co Ltd; HOVON Foundation; Janssen-Cilag; Otsuka Pharmaceutical; Sidney Kimmel Cancer Center; Xian-Janssen
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Sickle cell anaemia; Myelodysplastic syndromes; Chronic myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute myeloid leukaemia; Chronic myeloid leukaemia; Myelodysplastic syndromes
  • Phase I/II Ovarian cancer

Most Recent Events

  • 20 Apr 2017 The University of Southern California, in collaboration with National Cancer Institute initiates enrolment in a phase II trial for Acute-myeloid-leukaemia, Chronic-myeloid-leukaemia and Myelodysplastic-syndromes (Combination Therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (NCT03146871)
  • 17 Mar 2017 Phase-I clinical trials in Acute myeloid leukaemia (Combination therapy, Newly diagnosed) in USA (IV) (NCT03063944)
  • 30 Dec 2016 City of Hope Medical Center and National Cancer Institute plan a phase I trial for Acute myeloid leukaemia (Combination therapy) in USA (IV) (NCT03009240)
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