Drug Profile


Alternative Names: GS 0393; GS 393; Phosphonylmethoxyethyl-a; PMEA

Latest Information Update: 21 Aug 2007

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At a glance

  • Originator Academy of Sciences of the Czech Republic; Nonindustrial source; Rega Institute for Medical Research
  • Developer Academy of Sciences of the Czech Republic; Gilead Sciences; Nonindustrial source
  • Class Adenine nucleotides; Antiretrovirals; Phosphonic acids; Purine nucleotides; Small molecules
  • Mechanism of Action Cell differentiation stimulants; DNA-directed DNA polymerase inhibitors; Immunomodulators; Immunosuppressants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Cancer; Graft-versus-host disease; Hepatitis B; HIV infections; Rheumatic disorders

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 08 May 2000 Discontinued-II for HIV infections treatment in USA (IV)
  • 08 May 2000 Discontinued-Preclinical for Hepatitis B in USA (Unknown route)
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