Drug Profile


Alternative Names: GR-68755; GR-68755C; Lotronex

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator GlaxoSmithKline
  • Class Carbolines; Irritable bowel syndrome therapies; Small molecules
  • Mechanism of Action Serotonin 3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Irritable bowel syndrome
  • Discontinued Anxiety disorders; Cognition disorders; Non-ulcer dyspepsia; Schizophrenia

Most Recent Events

  • 31 Jul 2011 Prometheus Laboratories has been acquired by Nestle
  • 30 Nov 2007 Discontinued - Phase-II for Irritable bowel syndrome in Japan (PO)
  • 07 Nov 2007 Alosetron licensed to Prometheus Laboratories in USA
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