Drug Profile


Alternative Names: 2-CdA; 2-Chloro-2-deoxyadenosine; 2-Chlorodeoxyadenosine; 2CDA; Chlorodeoxyadenosine; Intocel; Leustat; Leustatin; Leustatine; Mavenclad; Movectro; Mylinax; N-l-Leucyl-doxorubicin; RWJ 26251

Latest Information Update: 10 Jul 2017

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At a glance

  • Originator Scripps Clinic
  • Developer EMD Serono; Janssen-Cilag; Merck Serono; Orphan Australia
  • Class Antineoplastics; Deoxyadenosines; Purine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Immunosuppressants; Purinergic P1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple sclerosis; Leukaemia; Lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic lymphocytic leukaemia; Hairy cell leukaemia; Leukaemia; Lymphoma; Multiple sclerosis
  • No development reported Psoriasis; Transplant rejection

Most Recent Events

  • 27 Jun 2017 Pharmacodynamics data from pooled analysis of phase III trials CLARITY, CLARITY Extension and ORACLE-MS in Multiple sclerosis presented at the 3rd Congress of the European Association of Neurology (EAN-2017)
  • 23 Jun 2017 The CHMP recommends approval of cladribine for Multiple sclerosis in European Union
  • 28 Apr 2017 Efficacy data from the retrospective subgroup analysis of phase III CLARITY trial in Multiple sclerosis presented at the the 69th Annual Meeting of the American Academy of Neurology (AAN-2017)
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