Mecasermin rinfabate

Drug Profile

Mecasermin rinfabate

Alternative Names: HGT-ROP-001; Insulin-like growth factor-I/insulin-like growth factor binding protein-3; IPLEX; Premiplex; rhIGF-I/rhIGFBP-3; SHP607; SomatoKine

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Insmed
  • Developer Insmed; Shire
  • Class Antihyperglycaemics; Growth factors
  • Mechanism of Action Insulin like growth factor binding protein 3 stimulants; Insulin-like growth factor I stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Insulin resistance; Growth disorders; Retinopathy of prematurity; Muscular dystrophies
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Retinopathy of prematurity
  • Market Withdrawal Growth disorders
  • Suspended Muscular dystrophies
  • No development reported Amyotrophic lateral sclerosis
  • Discontinued Burns; Fracture; Insulin resistance; Lipodystrophy; Postmenopausal osteoporosis; Short stature; Type 1 diabetes mellitus; Type 2 diabetes mellitus

Most Recent Events

  • 30 Jun 2016 Efficacy and adverse events data from a phase II trial in Retinopathy of prematurity released by Shire
  • 30 Jun 2016 Shire plans a phase III trial for Retinopathy of prematurity
  • 01 Mar 2016 Shire completes a phase II trial for Retinopathy of prematurity in Italy, Netherlands, Sweden, United Kingdom, Poland and USA (NCT01096784)
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