Drug Profile


Alternative Names: Amphibian ribonuclease A; Onconase; P-30 protein - Alfacell; P-30 ribonuclease

Latest Information Update: 11 Aug 2017

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At a glance

  • Originator Alfacell Corporation
  • Developer Alfacell Corporation; Tamir Biotechnology
  • Class Antineoplastics; Ribonucleases
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Protein synthesis inhibitors; Ribonuclease stimulants; Tubulin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma; Ebola virus infections
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Genital warts; Human papillomavirus infections
  • Preclinical Ebola virus infections; Zika virus infection
  • Discontinued Acute myeloid leukaemia; Brain cancer; Chronic lymphocytic leukaemia; HIV infections; Mesothelioma; Neuroblastoma; Pancreatic cancer; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 08 Aug 2017 Ranpirnase receives Orphan Drug status for Ebola virus infections in USA
  • 08 Mar 2017 Efficacy data from a phase I/II trial in Genital warts and Human papillomavirus infections released by Tamir Biotechnology
  • 01 Sep 2016 Tamir Biotechnology completes a phase I/II trial in Genital warts and Human papillomavirus infections in Bolivia (NCT02535104)
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