Drug Profile


Alternative Names: Hiltonol; P.I.C.L.C.; Poly-ICLC; Polyinosinic polycytidylic acid; Polyriboinosinic-polyribocytidylic acid

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Medical University of South Carolina; Oncovir
  • Developer Abramson Cancer Center of the University of Pennsylvania; Icahn School of Medicine at Mount Sinai; immatics biotechnologies GmbH; Ludwig Institute for Cancer Research; Medical University of South Carolina; Memorial Sloan-Kettering Cancer Center; New York University School of Medicine; Oncovir; Quest PharmaTech; University Hospitals of Geneva; University of California, San Diego; University of Pittsburgh; Washington University School of Medicine
  • Class Adjuvants; Antineoplastics; Antivirals; Biopolymers; Oligonucleotides
  • Mechanism of Action 2',5' oligoadenylate synthetase modulators; DDX58 protein modulators; IFIH1 protein modulators; Immunomodulators; Proto oncogene protein c rel modulators; Proto oncogene protein c-ret modulators; Toll-like receptor 3 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Brain cancer; Flavivirus infections; Orthopoxvirus infections
  • New Molecular Entity No

Highest Development Phases

  • Phase II Malignant melanoma; Ovarian cancer; Solid tumours
  • Phase I/II B cell lymphoma; Glioblastoma
  • Phase I Glioma; Prostate cancer
  • No development reported Anaplastic astrocytoma; Cytomegalovirus infections; HIV infections; Influenza virus infections; Pancreatic cancer; Smallpox

Most Recent Events

  • 06 Sep 2017 Immunogenecity and adverse events data from a phase I/II trial in Glioblastoma presented at the 3rd CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference (CRI-CIMT-EATI-AACR-2017)
  • 24 Jul 2017 Phase-I clinical trials in Glioblastoma (Newly diagnosed, Adjunctive treatment) in USA (NCT03223103)
  • 30 May 2017 OncoQuest initiates a phase Ib trial in Ovarian cancer (Recurrent, Late-stage disease, Combination therapy, Second-line therapy or greater) in USA (NCT03162562)
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