Drug Profile


Alternative Names: Ariclaim; Cymbalta; LY-227942; LY-248686; Xeristar; Yentreve

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Eli Lilly
  • Developer Eli Lilly; Shiga University of Medical Science; Shionogi
  • Class Antidepressants; Naphthalenes; Non-opioid analgesics; Propanolamines; Small molecules; Thiophenes
  • Mechanism of Action Adrenergic uptake inhibitors; Serotonin plasma membrane transport protein inhibitors; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Back pain; Depressive disorders; Diabetic neuropathies; Fibromyalgia; Generalised anxiety disorder; Major depressive disorder; Musculoskeletal pain; Neuropathic pain; Stress incontinence
  • Phase II/III Chronic fatigue syndrome

Most Recent Events

  • 01 Jul 2017 Shiga University of Medical Science, in collaboration with Shionogi, terminates phase II/III trial in Major depressive disorder (In adolescents) in Japan (E-DAD/UMIN000016192)
  • 19 Dec 2016 Launched for Musculoskeletal pain (associated with osteoarthritis) in Japan (PO)
  • 19 Dec 2016 Registered for Musculoskeletal pain (associated with osteoarthritis) in Japan (PO)
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