Lometrexol

Drug Profile

Lometrexol

Alternative Names: DDATHF; LY 264618; T 904064; T-64

Latest Information Update: 02 Dec 2003

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At a glance

  • Originator Dana-Farber Cancer Institute
  • Class 2 ring heterocyclic compounds; Amides; Glutamates; Pyrimidines
  • Mechanism of Action DNA synthesis inhibitors; Phosphoribosylglycinamide formyltransferase inhibitors; Tetrahydrofolate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No

Highest Development Phases

  • Discontinued Breast cancer; Cancer; Head and neck cancer; Malignant melanoma; Non-small cell lung cancer; Sarcoma; Solid tumours

Most Recent Events

  • 31 Jan 2003 Tularik has terminated its licensing agreement for T 64
  • 19 Jun 2002 Discontinued - Phase-II for Breast cancer in Australia (IV)
  • 19 Jun 2002 Discontinued - Phase-II for Breast cancer in Netherlands (IV)
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