Plerixafor

Drug Profile

Plerixafor

Alternative Names: AMD 3100; JM 3100; Mozobil; Plerixafor-hydrochloride; SDZ SID 791

Latest Information Update: 22 Jun 2017

Price : $50

At a glance

  • Originator Genzyme Corporation; Rega Institute for Medical Research
  • Developer Dana-Farber Cancer Institute; Genzyme Corporation; Memorial Sloan-Kettering Cancer Center; Sanofi; Sanofi Genzyme
  • Class Antineoplastics; Heterocyclic compounds; Polyamines; Small molecules
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Stem cell mobilisation
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Stem cell mobilisation
  • Phase I/II Acute myeloid leukaemia
  • Phase I Chronic lymphocytic leukaemia; Glioma; Sickle cell anaemia
  • No development reported Myocardial infarction
  • Discontinued HIV infections; Rheumatoid arthritis

Most Recent Events

  • 09 May 2017 Genzyme completes the phase I/II MOZAIC trial in Stem cell mobilisation (In adolescents, In children, In Infants) in France, Germany, Italy, the UK, Belgium, Czech Republic, Denmark, Hungary, Israel, the Netherlands, Spain and Poland (NCT01288573)
  • 01 Dec 2016 Genzyme completes a phase I/II trial in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in Spain (IV) (NCT01435343)
  • 01 Sep 2016 Sanofi and Genzyme completes a phase II trial for Stem cell mobilisation in patients with multiple myeloma (Late-stage disease, Combination therapy) in Belgium, Estonia, Lithuania and Sweden (NCT01753453)
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