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Plerixafor - Sanofi

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Drug Profile

Plerixafor - Sanofi

Alternative Names: AMD 3100; JM 3100; LM-3100; Mozobil; Plerixafor-hydrochloride; SDZ SID 791

Latest Information Update: 09 Apr 2025

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At a glance

  • Originator Genzyme Corporation; Rega Institute for Medical Research
  • Developer Dana-Farber Cancer Institute; Memorial Sloan-Kettering Cancer Center; Sanofi
  • Class Antineoplastics; Heterocyclic compounds; Polyamines; Small molecules
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Stem cell mobilisation
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Stem cell mobilisation
  • Phase II Glioma
  • Phase I/II Acute myeloid leukaemia; Multiple myeloma
  • No development reported Chronic lymphocytic leukaemia; Colorectal cancer; Myocardial infarction; Ovarian cancer; Pancreatic cancer; Sickle cell anaemia
  • Discontinued HIV infections; Rheumatoid arthritis

Most Recent Events

  • 27 Mar 2025 Memorial Sloan Kettering Cancer Center completes a phase-I clinical trials in Sickle cell anaemia in USA (SC) (NCT02193191)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Pancreatic-cancer(Late-stage disease, Second-line therapy or greater) in United Kingdom (IV, Infusion)
  • 29 Nov 2022 Phase-II development for Glioma and Glioblastoma (Combination therapy, Late-stage disease, Newly diagnosed) is ongoing in USA (IV) (NCT03746080)

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