Nolatrexed

Drug Profile

Nolatrexed

Alternative Names: AG 337; Nolatrexed dihydrochloride; Orataq; Thymitaq; ZX337

Latest Information Update: 17 Aug 2017

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At a glance

  • Originator Agouron Pharmaceuticals
  • Developer Agouron Pharmaceuticals; YM BioSciences USA
  • Class Quinazolines; Small molecules
  • Mechanism of Action Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatocellular carcinoma
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Colorectal cancer; Head and neck cancer; Hepatocellular carcinoma; Lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 09 May 2006 Eximias Pharmaceutical Corporation has been acquired by YM BioSciences
  • 04 Aug 2005 Eximias presented results showing that the ETHECC trial did not meet its primary endpoint
  • 22 Apr 2005 Eximias has completed enrolment in the ETHECC trial for Hepatocellular carcinoma in Canada, Europe, South Africa and USA
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