Midostaurin

Drug Profile

Midostaurin

Alternative Names: 4-N-benzoyl staurosporine; Benzoylstaurosporine; CGP 41251; N-benzoyl-staurosporine; PKC412; PKC412A; Rydapt

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Novartis
  • Developer Mayo Clinic; National Cancer Institute (USA); Novartis; Novartis Oncology; Ohio State University Comprehensive Cancer Center
  • Class Antineoplastics; Carbazoles; Eye disorder therapies; Indole alkaloids; Skin disorder therapies; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Multidrug resistance-associated protein inhibitors; Platelet-derived growth factor receptor antagonists; Protein kinase C inhibitors; Proto oncogene protein c-kit inhibitors; Signal transduction pathway inhibitors; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Systemic mastocytosis
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Acute myeloid leukaemia; Systemic mastocytosis
  • Discontinued Acute lymphoblastic leukaemia; Colorectal cancer; Diabetic macular oedema; Gastrointestinal stromal tumours; Multiple myeloma

Most Recent Events

  • 03 May 2017 Discontinued - Phase-I/II for Acute lymphoblastic leukaemia (In adolescents, In children, In infants, Second-line therapy or greater) in Sweden, Netherlands, Italy, France and USA (PO)
  • 02 May 2017 The National Cancer Institute and Stanford University plans a phase II extension trial for Acute myeloid leukaemia (In the elderly) in USA (PO) (NCT02723435)
  • 28 Apr 2017 Adverse events data from the phase III RATIFY trial in Acute myeloid leukaemia released
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