Drug Profile


Alternative Names: Methyl-G; Methyl-GAG; MGBG; Mitoguazone dihydrochloride; NSC 32946; Zyrkamine

Latest Information Update: 13 Nov 1998

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At a glance

  • Originator Cancer Therapy and Research Center
  • Class Antineoplastics; Guanidines
  • Mechanism of Action Adenosylmethionine decarboxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Non-Hodgkin's lymphoma; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer

Most Recent Events

  • 13 Nov 1998 Discontinued-Clinical for Prostate cancer in USA (IV)
  • 13 Nov 1998 Discontinued-II for Non-small cell lung cancer in USA (IV)
  • 13 Nov 1998 Discontinued-preregistration for Non-Hodgkin's lymphoma in USA (IV)
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