Drug Profile


Alternative Names: Comtan; Comtess; OR 611

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Orion
  • Developer Novartis
  • Class Antiparkinsonians; Catechols; Nitriles; Small molecules
  • Mechanism of Action Catechol-O-methyltransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Parkinson's disease
  • Discontinued Restless legs syndrome

Most Recent Events

  • 16 Feb 2017 Eisai acquires marketing rights for entacapone from Orion Pharma in China
  • 15 Dec 2016 Biomarkers information updated
  • 20 Aug 2012 First generic equivalent approved in US for Parkinson's disease
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