Alvocidib

Drug Profile

Alvocidib

Alternative Names: Alvocidib hydrochloride; Flavopiridol; HL-275; HMR 1275; IND 46211; L 868275; MDL-107826A; NSC 649890

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator sanofi-aventis
  • Developer National Cancer Institute (USA); Tolero Pharmaceuticals
  • Class Antineoplastics; Flavonoids; Piperidines; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; CDC2 protein kinase inhibitors; Cyclin dependent kinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Germ cell and embryonal neoplasms
  • Phase I B cell lymphoma
  • Preclinical Myelodysplastic syndromes
  • No development reported Chronic lymphocytic leukaemia
  • Discontinued HIV infections; Multiple myeloma; Non-small cell lung cancer; Oesophageal cancer; Renal cancer; Reperfusion injury

Most Recent Events

  • 26 Jan 2017 Tolero Pharmaceuticals has been acquired by Sumitomo Dainippon Pharma
  • 28 Dec 2016 Preclinical trials in Myelodysplastic syndromes in USA (IV) before December 2016
  • 29 Apr 2016 Biomarkers information updated
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