Drug Profile


Alternative Names: 5-Ethynyluracil; 5-EU; 776C85; ADH 300004; GW 776C85

Latest Information Update: 17 Aug 2015

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At a glance

  • Originator GlaxoSmithKline
  • Developer Adherex Technologies; Fennec Pharmaceuticals; GlaxoSmithKline
  • Class Antineoplastics; Chemosensitisers; Pyrimidinones; Small molecules
  • Mechanism of Action Dihydropyrimidine dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Suspended Breast cancer
  • Discontinued Colorectal cancer; Erythrodysaesthesia; Head and neck cancer; Hepatocellular carcinoma; Pancreatic cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 03 Sep 2014 Adherex is now called Fennec Pharmaceuticals
  • 09 Aug 2013 Eniluracil is available for licensing as of 09 Aug 2013. www.adherex.com
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