Drug Profile


Alternative Names: Cytolex; Locilex; MSI-78; Pexiganan acetate

Latest Information Update: 21 Apr 2017

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At a glance

  • Originator Genaera Corporation
  • Developer Genaera Corporation; PLx Pharma; RRD International
  • Class Antibacterials; Antimicrobial cationic peptides; Peptide antibiotics
  • Mechanism of Action Cell membrane permeability enhancers; Defensin stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diabetic foot ulcer
  • Phase I Skin and soft tissue infections
  • Discontinued Impetigo

Most Recent Events

  • 19 Apr 2017 Dipexium Pharmaceuticals has been acquired and merged into PLx Pharma
  • 28 Feb 2017 Dipexium Pharmaceuticals has patents pending for Pexiganan (Locilex®) in Brazil, Canada, China, Eurasia, Indonesia, Mexico, Singapore and South Africa (Dipexium Annual report 2016)
  • 07 Sep 2016 Dipexium Pharamaceuticals receives notice of allowance for patents related to pexiganan cream 0.8% in South Korea and Hong Kong
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