Fosbretabulin

Drug Profile

Fosbretabulin

Alternative Names: CA4DP; CA4P; Combretastatin A-4 phosphate - Mateon Therapeutics; Combretastatin A4 prodrug; Combretastatin-A4; Combretastatin-A4 phosphate; CRC 87-09; CRC-98-09; CS-A4; Fosbretabulin disodium; Fosbretabulin tromethamine; NSC-613729; Zybrestat®

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Arizona State University
  • Developer Mateon Therapeutics; National Cancer Institute (USA); OXiGENE; University of Kentucky
  • Class Antineoplastics; Combretastatins; Small molecules; Stilbenes
  • Mechanism of Action Cadherin 5 inhibitors; Tubulin polymerisation inhibitors; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Glioma; Thyroid cancer; Neuroendocrine tumours
  • New Molecular Entity Yes
  • Available For Licensing Yes - Eye disorders; Ovarian cancer

Highest Development Phases

  • Discontinued Age-related macular degeneration; Choroidal neovascularisation; Colorectal cancer; Diabetic retinopathy; Fallopian tube cancer; Gastrointestinal cancer; Head and neck cancer; Leukaemia; Malignant carcinoid syndrome; Neuroendocrine tumours; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Psoriasis; Rheumatoid arthritis; Thyroid cancer

Most Recent Events

  • 26 Sep 2017 Discontinued - Phase-I for Neuroendocrine tumours (Metastatic disease, Inoperable/Unresectable, Combination therapy, Second-line therapy or greater) in USA (IV)
  • 26 Sep 2017 Discontinued - Phase-I/II for Colorectal cancer in United Kingdom (IV)
  • 26 Sep 2017 Discontinued - Phase-I/II for Head and neck cancer in USA (IV)
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