Drug Profile


Alternative Names: ConXn; Reasanz; Recombinant human relaxin H2; Recombinant relaxin; Relaxin; Relaxin H2; rhRlx; RLX-030; RLX-030A; SUN-Y8002

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Howard Florey Institute
  • Developer Corthera; Genentech; Novartis
  • Class Heart failure therapies; Peptide hormones
  • Mechanism of Action Peptide hormone stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute heart failure
  • Phase II Chronic heart failure; Coronary artery disease; Liver cirrhosis; Portal hypertension
  • Discontinued Diffuse scleroderma; Female infertility; Fibrosis; Labour disorders; Labour induction; Peripheral arterial disorders; Preeclampsia; Pulmonary fibrosis; Pulmonary hypertension

Most Recent Events

  • 12 Jul 2017 Novartis terminates the phase III RELAX AHF-Pan EU trial for Acute heart failure (Adjunctive treatment) based on results from pivotal adult AHF study CRLX030A2301 in Austria, Belgium, Denmark, Hungary, Italy, Bulgaria, Croatia, Czech Republic, Estonia, Finland, France, Germany, Greece, Iceland, Latvia, Lithuania, Poland, Portugal, Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Switzerland and the UK (IV) (NCT02064868)
  • 16 Jun 2017 Novartis terminates phase III trial in Acute heart failure (Adjunctive treatment) in Japan, South Korea, Philippines, Thailand, Taiwan, Malaysia, Hong Kong, China, India, Jordan, Lebanon, based on results from pivotal adult AHF study CRLX030A2301 (NCT02007720)
  • 24 May 2017 Novartis terminates a phase II trial in Acute heart failure (In infants, In children, In adolescents) in the US, Germany, Switzerland and the United Kingdom (NCT02151383)
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