Pemetrexed

Drug Profile

Pemetrexed

Alternative Names: Alimta; LY-231514; LY-231514 disodium; MTA; Multi-targeted antifolate; Pemetrexed disodium

Latest Information Update: 19 Jun 2017

$50 / €47 *
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At a glance

  • Originator Eli Lilly
  • Developer Eli Lilly; University of California, Davis; Virginia Commonwealth University
  • Class Antineoplastics; Benzamides; Glutamates; Hypoxanthines; Small molecules
  • Mechanism of Action Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mesothelioma; Non-small cell lung cancer
  • Phase II Breast cancer
  • Phase I/II Solid tumours
  • No development reported Head and neck cancer; Non-Hodgkin's lymphoma; Osteosarcoma; Ovarian cancer; Renal cell carcinoma
  • Discontinued Small cell lung cancer

Most Recent Events

  • 13 Jun 2017 Roche plans a phase II/III trial for Non-small cell lung cancer(Monotherapy, Combination therapy, Inoperable/unresectable, Metastatic disease, Late-stage disease) in USA, Australia, Belgium, Brazil, Canada, France, Hong Kong, Italy, South Korea, Mexico, Poland, Spain and Thailand (NCT03178552)
  • 16 May 2017 Eli Lilly terminates a phase I/II trial in Solid tumours (Metastatic disease, Late-stage disease, Second-line therapy or greater, Combination therapy) in USA as practice patterns with pemetrexed have evolved (IV) (NCT00470548)
  • 07 Oct 2016 Pooled results from the phase III and phase IV trials presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
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