Pemetrexed

Drug Profile

Pemetrexed

Alternative Names: Alimta; LY-231514; LY-231514 disodium; MTA; Multi-targeted antifolate; Pemetrexed disodium

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Eli Lilly
  • Developer Eli Lilly; Virginia Commonwealth University
  • Class Antineoplastics; Benzamides; Glutamates; Hypoxanthines; Small molecules
  • Mechanism of Action Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mesothelioma; Non-small cell lung cancer
  • Phase II Breast cancer
  • No development reported Head and neck cancer; Non-Hodgkin's lymphoma; Osteosarcoma; Ovarian cancer; Renal cell carcinoma
  • Discontinued Small cell lung cancer

Most Recent Events

  • 07 Oct 2016 Pooled results from the phase III and phase IV trials presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 07 Oct 2016 Updated efficacy data from the phase III trial in Non-small cell lung cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 07 Oct 2016 Interim efficacy and adverse event data from a phase II trial in Non-small cell lung cancer (Combination therapy, First-line therpy, Metastatic disease) presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
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