Pemetrexed

Drug Profile

Pemetrexed

Alternative Names: Alimta; LY-231514; LY-231514 disodium; MTA; Multi-targeted antifolate; Pemetrexed disodium

Latest Information Update: 01 Dec 2017

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At a glance

  • Originator Eli Lilly
  • Developer Eli Lilly; University of California, Davis; Virginia Commonwealth University
  • Class Antineoplastics; Benzamides; Glutamates; Hypoxanthines; Small molecules
  • Mechanism of Action Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mesothelioma; Non-small cell lung cancer
  • Phase II Breast cancer
  • Phase I/II Solid tumours
  • No development reported Head and neck cancer; Non-Hodgkin's lymphoma; Osteosarcoma; Ovarian cancer; Renal cell carcinoma
  • Discontinued Small cell lung cancer

Most Recent Events

  • 14 Nov 2017 Roche initiates enrolment in a phase I/II trial for Non-small cell lung cancer (Combination therapy, Metastatic disease) in Australia (IV) (NCT03337698)
  • 05 Oct 2017 Patent Trial and Appeal Board of the USPTO ruled in the favor of Eli Lilly for patentability of the vitamin regimen for pemetrexed in USA
  • 22 Sep 2017 Roche initiates enrolment in the phase II/III B-FAST trial for Non-small cell lung cancer (Monotherapy, Combination therapy, Metastatic disease, Inoperable/Unresectable, Late-stage disease, Second-line therapy or greater) in USA, Australia, Canada, Chile, Italy, South Korea, Poland, Spain (EudraCT2017-000076-28) (NCT03178552)
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