Ibudilast

Drug Profile

Ibudilast

Alternative Names: AV-11; AV-411; Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos

Latest Information Update: 13 Feb 2017

Price : $50

At a glance

  • Originator Kyorin Pharmaceutical
  • Developer Banyu; Kyorin Pharmaceutical; MediciNova; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Senju Pharmaceutical; University of California at Los Angeles; University of Colorado at Boulder
  • Class 2 ring heterocyclic compounds; Anti-inflammatories; Antiasthmatics; Antihyperglycaemics; Antiplatelets; Non-opioid analgesics; Nootropics; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Astrocyte inhibitors; Cytokine modulators; Glial cell modulators; Leukotriene receptor antagonists; Macrophage migration inhibitory factor inhibitors; Nitric oxide synthase inhibitors; Phosphodiesterase 10A inhibitors; Toll-like receptor 4 antagonists; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis; Globoid cell leukodystrophy
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Amyotrophic lateral sclerosis; Multiple sclerosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Allergic conjunctivitis; Asthma; Cerebrovascular disorders
  • Phase II Alcoholism; Amyotrophic lateral sclerosis; Multiple sclerosis; Opioid abuse
  • Phase I Drug abuse
  • Preclinical Brain injuries; Globoid cell leukodystrophy
  • Suspended Neuropathic pain
  • No development reported Headache
  • Discontinued Diabetic neuropathies; Diabetic retinopathy

Most Recent Events

  • 07 Feb 2017 Pharmacodynamics data from a phase Ib trial in Opioid Use released by MediciNova
  • 23 Jan 2017 Updated efficacy and adverse events data from a phase IIa trial in Alcoholism released by MediciNova
  • 20 Dec 2016 Ibudilast receives Orphan Drug status for Amyotrophic lateral sclerosis in European Union
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