Ibudilast- MediciNova

Drug Profile

Ibudilast- MediciNova

Alternative Names: AV-11; AV-411; Eyevinal; Ibinal; KC-404; Ketas; MN-166; Pinatos

Latest Information Update: 15 Nov 2017

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At a glance

  • Originator Kyorin Pharmaceutical
  • Developer Banyu; Kyorin Pharmaceutical; MediciNova; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Senju Pharmaceutical; University of California at Los Angeles; University of Colorado at Boulder; University of New South Wales
  • Class 2 ring heterocyclic compounds; Anti-inflammatories; Antiasthmatics; Antihyperglycaemics; Antiplatelets; Non-opioid analgesics; Nootropics; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Astrocyte inhibitors; Cytokine modulators; Glial cell modulators; Leukotriene receptor antagonists; Macrophage migration inhibitory factor inhibitors; Nitric oxide synthase inhibitors; Phosphodiesterase 10A inhibitors; Toll-like receptor 4 antagonists; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis; Globoid cell leukodystrophy
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Allergic conjunctivitis; Asthma; Cerebrovascular disorders
  • Phase II Alcoholism; Amyotrophic lateral sclerosis; Drug abuse; Multiple sclerosis; Opioid abuse
  • Preclinical Glioblastoma; Globoid cell leukodystrophy
  • Suspended Neuropathic pain
  • No development reported Brain injuries; Headache
  • Discontinued Diabetic neuropathies; Diabetic retinopathy

Most Recent Events

  • 09 Nov 2017 MediciNova, Department of Veterans Affairs and Oregon Health & Science University agree to co-develop ibudilast for Drug abuse (methamphetamine use disorder)
  • 09 Nov 2017 MediciNova in collaboration with Department of Veterans Affairs and Oregon Health & Science University plans a biomarker study of ibudilast for Drug abuse (methamphetamine use disorder)
  • 04 Nov 2017 No recent reports of development identified for preclinical development in Brain injuries in USA (Parenteral)
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