Drug Profile


Alternative Names: ACT-050088; Bosentan monohydrate; RO-470203; RO-470203-029; Tracleer

Latest Information Update: 27 Jun 2017

Price : $50

At a glance

  • Originator Roche
  • Developer Actelion Pharmaceuticals
  • Class Antihypertensives; Pyrimidines; Small molecules; Sulfonamides
  • Mechanism of Action Endothelin A receptor antagonists; Endothelin B receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary hypertension; Skin ulcer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension; Skin ulcer
  • No development reported Diabetic foot ulcer
  • Discontinued Asthma; Heart failure; Inflammatory bowel diseases; Ischaemic heart disorders; Kidney disorders; Malignant melanoma; Myocardial infarction; Pulmonary fibrosis; Reperfusion injury; Transplant rejection

Most Recent Events

  • 16 Jun 2017 Actelion Pharmaceuticals has been acquired by Janssen Pharmaceuticals
  • 08 Nov 2016 Launched for Skin ulcer in Japan (PO)
  • 30 Sep 2016 Actelion Pharmaceuticals completes a phase-III clinical trial in Pulmonary arterial hypertension (In adolescents, In children, In infants, In neonates) in Japan (PO) (Japic-CTI132155)
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