Drug Profile


Alternative Names: BENSPM; CI 1006; DE 333; DENSPM; N-N-diethylnorspermine

Latest Information Update: 20 Dec 2016

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At a glance

  • Originator Genzyme Corporation
  • Developer Genzyme Corporation; Nippon Kayaku; University of Toronto
  • Class Antineoplastics; Polyamines; Small molecules
  • Mechanism of Action Adenosylmethionine decarboxylase inhibitors; Ornithine decarboxylase inhibitors; Spermidine-spermine N1-acetyltransferase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity No

Highest Development Phases

  • Discontinued Alzheimer's disease; Cancer; Liver cancer; Psoriasis

Most Recent Events

  • 23 Aug 2007 Discontinued - Phase-I for Cancer in Japan (IV)
  • 28 Apr 2006 This compound is still in active development for Liver cancer
  • 30 Jul 2004 Phase-I/II clinical trials in Liver cancer in USA (IV)
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