Drug Profile


Alternative Names: Anti-interleukin-6 monoclonal antibody - Centocor; cCLB8; Chimeric anti-interleukin-6 monoclonal antibody - Centocor; CNTO-328; Sylvant

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Centocor
  • Developer Centocor; Janssen Biotech
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Interleukin 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Giant lymph node hyperplasia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Giant lymph node hyperplasia
  • Phase II Multiple myeloma
  • Phase I Paraproteinaemia
  • Discontinued Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Prostate cancer; Renal cell carcinoma

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 18 Jun 2015 Siltuximab is still in phase II trials for smoldering Multiple myeloma (First-line therapy, Monotherapy) in USA, Australia, Belgium, France, Germany, Greece, Israel, South Korea, Spain, Sweden and the United Kingdom
  • 14 May 2015 Siltuximab is still in phase II trials for Giant lymph node hyperplasia in Australia, Brazil, China, Egypt, Hong Kong, India, Israel, Malaysia, New Zealand, Russia, Singapore, South Korea and Taiwan
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