Drug Profile


Alternative Names: BBR-2278; BBR-2778; Pixantrone dimaleate; Pixuvri

Latest Information Update: 03 May 2017

Price : $50

At a glance

  • Originator University of Vermont
  • Developer Cell Therapeutics; CTI BioPharma
  • Class Anthracyclines; Anthraquinones; Antineoplastics; Isoquinolines; Small molecules
  • Mechanism of Action Alkylating agents; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-Hodgkin's lymphoma
  • Phase III Diffuse large B cell lymphoma; Follicular lymphoma
  • Phase I Cancer
  • Discontinued Breast cancer; Myasthenia gravis

Most Recent Events

  • 25 Apr 2017 Pixantrone licensed to Servier in all countries world-wide excluding Israel and USA
  • 02 Mar 2017 CTI Biopharma has patent protection for pixantrone in USA, Europe Union and other countries (CTI Biopharma's form 10-K, filed in March 2017)
  • 11 Jan 2017 Phase-III clinical trials in Diffuse large B cell lymphoma (Combination therapy, Second-line therapy or greater) in Slovakia, Russia, Romania, France, Denmark, Czech Republic, Bulgaria, Belgium and Austria (IV) before January 2017 (NCT01321541),
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