Drug Profile


Alternative Names: BBR-2278; BBR-2778; Pixantrone dimaleate; Pixuvri

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator University of Vermont
  • Developer Cell Therapeutics; CTI BioPharma
  • Class Anthracyclines; Anthraquinones; Antineoplastics; Isoquinolines; Small molecules
  • Mechanism of Action Alkylating agents; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-Hodgkin's lymphoma
  • Phase III Diffuse large B cell lymphoma; Follicular lymphoma
  • Phase I Cancer
  • Discontinued Breast cancer; Myasthenia gravis

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Cancer(Metastatic disease) in USA (IV)
  • 02 Aug 2017 CTI BioPharma completes enrolment in the phase III PIX306 trial for Diffuse large B-cell lymphoma(Combination therapy, Second-line therapy or greater) in Austria, Belgium, Bulgaria, Czech Republic, Denmark, France, Germany, Hungary, Italy, Poland, Romania, Russia, Slovakia, Spain, Ukraine, United Kingdom and USA
  • 25 Apr 2017 Pixantrone licensed to Servier in all countries world-wide excluding Israel and USA
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