Drug Profile


Alternative Names: LACI; SC 59735; TFP561; TFPI - Chiron/Pfizer; Tissue factor pathway inhibitor - Chiron/Pfizer

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Chiron
  • Developer Novartis
  • Class Antithrombotics; Biological proteins
  • Mechanism of Action Factor Xa inhibitors; Tissue factor-factor VIIa complex inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Community-acquired pneumonia; Reperfusion injury; Septic shock; Thrombosis

Most Recent Events

  • 28 Jan 2009 Development discontinued for Community-acquired pneumonia during 2008
  • 22 Apr 2008 Pharmacodynamics data from a preclinical trial against Escherichia coli infection (related to Community-acquired pneumonia) presented at the 18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID-2008)
  • 22 May 2007 Tifacogin is still in active development
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