Drug Profile


Alternative Names: Metalyse; RG3625; TNK; TNK-tPA; TNKase

Latest Information Update: 26 Sep 2014

Price : $50

At a glance

  • Originator Genentech
  • Developer Boehringer Ingelheim; Genentech; Roche Canada
  • Class Blood coagulation factors; Plasminogen activator enzymes; Serine endopeptidases; Thrombolytics
  • Mechanism of Action Plasminogen activators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myocardial infarction
  • Discontinued Catheter thrombosis; Heart arrest

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 13 Mar 2013 Discontinued - Phase-III for Catheter thrombosis in USA (IV)
  • 11 Mar 2013 Efficacy and adverse events data from the Phase-III STREAM trial in Myocardial infarction presented at the 62nd Annual Scientific Session of the American College of Cardiology (ACC-2013)
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