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Cetuximab - Eli Lilly and Company

Drug Profile

Cetuximab - Eli Lilly and Company

Alternative Names: Anti-EGFR monoclonal antibody 225; C 225; ch 225; Erbitux; IMC-C225; LY-2939777

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator University of California
  • Developer Array BioPharma; Bristol-Myers Squibb; Celldex Therapeutics Inc; Centre Jean Perrin; Eli Lilly; Eli Lilly and Company; Fudan University; Merck KGaA; National Cancer Institute (USA); New York University School of Medicine; Novartis; Pfizer; Pierre Fabre; Radiation Therapy Oncology Group; Roche; UNICANCER; University of Michigan Comprehensive Cancer Center
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Antibody-dependent cell cytotoxicity; Epidermal growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Squamous cell cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Head and neck cancer
  • Phase III Non-small cell lung cancer
  • Phase II Bladder cancer; Breast cancer; Gastric cancer; Malignant-mesothelioma; Rectal cancer; Squamous cell cancer
  • Phase I/II Adenoid cystic carcinoma; Solid tumours
  • Phase Unknown Oesophageal cancer
  • No development reported Pancreatic cancer; Prostate cancer

Most Recent Events

  • 20 Oct 2023 Updated efficacy and adverse event data from a phase II trial in squamous cell carcinoma presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 03 Apr 2023 Celldex Therapeutics terminates a phase II trial in Head and neck cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA due to sponsor decision based on emerging risk-benefit profile (NCT03254927)
  • 10 Nov 2022 Merck KGaA, Array BioPharma and Pierre Fabre completes the phase III BEACON CRC trial in Colorectal cancer (Second-line therapy or greater, Metastatic disease, Combination therapy) in Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Czech Republic, Denmark, England, France, Germany, Hungary, Israel, Italy, Japan, Mexico, Netherlands, Norway, Poland, Russia, Scotland, South Korea, Spain, Taiwan, Turkey, Ukraine, United Kingdom, USA (PO) (NCT02928224) (EudraCT2015-005805-35)
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