Drug Profile


Alternative Names: AQ4N; AZD 1689

Latest Information Update: 02 Feb 2011

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At a glance

  • Originator University of London School of Pharmacy
  • Developer Novacea; Transcept Pharmaceuticals Inc
  • Class Anthraquinones; Antineoplastics; Small molecules
  • Mechanism of Action DNA intercalators; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Acute lymphoblastic leukaemia; B cell lymphoma; Glioblastoma

Most Recent Events

  • 02 Feb 2009 Novacea has merged with Transcept Pharmaceuticals to form Transcept Pharmaceuticals Inc
  • 15 Feb 2008 Pharmacokinetics data from a phase I proof-of-principle trial in solid tumours released by Novacea
  • 03 Jan 2008 Novacea has scaled back development of banoxantrone, discontinuing the phase II trial in acute lymphoblastic leukaemia and delaying the planned clinical trial in B cell lymphoma
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