Drug Profile


Alternative Names: IPM-tris; Isophosphamide mustard-tris; Isophosphoramide mustard; Palifosfamide-tris; ZIO-201; ZIO-201-T; Zymafos

Latest Information Update: 09 Dec 2015

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At a glance

  • Originator Dekk-Tec
  • Developer ZIOPHARM Oncology
  • Class Antineoplastics; Cyclophosphamides; Oxazines; Small molecules
  • Mechanism of Action Alkylating agents; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Small cell lung cancer
  • Phase II Breast cancer; Germ cell and embryonal neoplasms; Ovarian cancer; Testicular cancer
  • Phase I Solid tumours
  • Preclinical Haematological malignancies
  • Discontinued Soft tissue sarcoma

Most Recent Events

  • 24 Jul 2015 ZIOPHARM terminates a phase-II clinical trial in Germ cell cancer (Late-stage disease, Second-line therapy or greater) in USA due to slow accural
  • 03 Dec 2014 ZIOPHARM completes a phase III trial in Small cell lung cancer in Hungary, Poland and Germany (EudraCT2011-006134-17)
  • 01 Dec 2014 ZIOPHARM completes a phase II trial in Breast cancer (combination therapy, metastatic or recurrent disease, second-line or greater therapy) in USA (NCT01703754)
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