Drug Profile


Alternative Names: Ecteinascidin; Ecteinascidin-743; ET-743; NSC-684766; Yondelis

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator University of Illinois
  • Developer European Organisation for Research and Treatment of Cancer; Johnson & Johnson; PharmaMar; Taiho Pharmaceutical
  • Class Antineoplastics; Dioxoles; Small molecules; Tetrahydroisoquinolines
  • Mechanism of Action Alkylating agents; DNA synthesis inhibitors; Macrophage inhibitors; P-glycoprotein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Ovarian cancer; Soft tissue sarcoma
  • Phase III Fallopian tube cancer; Peritoneal cancer
  • Phase II Liposarcoma; Meningioma; Mesothelioma
  • No development reported Breast cancer; Prostate cancer

Most Recent Events

  • 01 Aug 2017 Phase-III clinical trials in Soft tissue sarcoma (Metastatic disease, Late-stage disease, Inoperable/Unresectable) in Spain, Poland, Germany (IV) (NCT02929394) (EudraCT2016-003535-38)
  • 14 Jun 2017 Efficacy and adverse events data from a phase II trial in Mesothelioma presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 02 Jun 2017 Updated efficacy and adverse events data from a phase III trial in Liposarcoma or leiomyosarcoma (Second-line therapy or greater) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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