Drug Profile


Alternative Names: Abegrin; Anti-alpha-v-beta-3 humanised monoclonal antibody; Anti-αvβ3 monoclonal antibody; LM 609; MEDI-522; Vitaxin; Vitaxin II

Latest Information Update: 21 Jun 2007

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At a glance

  • Originator Applied Molecular Evolution; MedImmune
  • Developer Targesome
  • Class Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Apoptosis stimulants; Immunostimulants; Integrin alphaVbeta3 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Discontinued Colorectal cancer; Malignant melanoma; Prostate cancer; Psoriasis; Rheumatoid arthritis

Most Recent Events

  • 19 Jun 2007 MedImmune has been acquired by AstraZeneca
  • 09 Mar 2007 Discontinued - Phase-II for Malignant melanoma in USA (IV-infusion)
  • 09 Mar 2007 Discontinued - Phase-II for Prostate cancer in USA (IV-infusion)
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