Iodine I 131 tositumomab

Drug Profile

Iodine I 131 tositumomab

Alternative Names: 131-I-anti-B1 antibody; 131-I-tositumomab; Anti-CD20 murine monoclonal antibody-I-131; B1; Bexxar; I-131 anti-B1 antibody; Iodine 131 tositumomab; Iodine-131 anti-B1 antibody; Tositumomab; TST/I131-TST

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Corixa Corp
  • Developer GlaxoSmithKline
  • Class Antineoplastics; Immunoconjugates; Monoclonal antibodies; Radiopharmaceuticals
  • Mechanism of Action Apoptosis stimulants; Immunostimulants; Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Market Withdrawal Non-Hodgkin's lymphoma
  • Discontinued Mantle-cell lymphoma

Most Recent Events

  • 20 Feb 2014 Withdrawn for Non-Hodgkin's lymphoma (Refractory metastatic disease) in USA and Canada (IV)
  • 07 Aug 2013 GlaxoSmithKline announces intention to withdraw iodine I 131 tositumomab (Barrax®) from the market in USA and Canada on 20 February 2014
  • 01 Jun 2013 GlaxoSmithKline and Corixa complete a phase II clinical trial in Mantle cell lymphoma (first-line combination therapy) in USA (NCT00992992)
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