Drug Profile


Alternative Names: EPO 906; Epothilone B

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Novartis
  • Class Antineoplastics; Epothilones
  • Mechanism of Action Mitosis inhibitors; Tubulin modulators; Tubulin polymerisation promoters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Brain cancer; Breast cancer; Colorectal cancer; Hepatocellular carcinoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 30 Sep 2012 Novartis completes a phase II trial in Prostate cancer (Hormone-refractory, Metastatic disease) in Australia, Belgium, France, Germany, Italy, Singapore, Spain and USA (NCT00411528)
  • 13 Jun 2012 Novartis completes a phase I trial of patupilone in combination with everolimus in Solid tumours (refractory disease) in USA (NCT00496600)
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