Drug Profile


Alternative Names: Estradiol/trimegestone oral; Totelle; Totelle Ciclico; Totelle Continuo; Totelle Cycle; Totelle Sekvens; Trimegestone/estradiol oral

Latest Information Update: 16 Aug 2010

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At a glance

  • Originator sanofi-aventis; Wyeth
  • Developer Pfizer; Wyeth
  • Class Estradiol congeners; Estrenes; Hormonal replacements; Norpregnadienes
  • Mechanism of Action Estrogen receptor agonists; Progesterone receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Menopausal syndrome; Postmenopausal osteoporosis

Most Recent Events

  • 16 Aug 2010 Launched for Postmenopausal osteoporosis in European Union (PO)
  • 16 Oct 2009 Wyeth has been acquired by Pfizer
  • 17 Mar 2009 Launched for Menopausal syndrome in Europe (PO)
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