Ipilimumab - Bristol-Myers Squibb

Drug Profile

Ipilimumab - Bristol-Myers Squibb

Alternative Names: Anti CTLA-4 monoclonal antibody - Medarex; BMS-734016; MDX-010; MDX-CTLA-4; Yervoy

Latest Information Update: 18 Oct 2017

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At a glance

  • Originator Medarex
  • Developer AIO Studien gGmbH; Bavarian Nordic; Big Ten Cancer Research Consortium; Bristol-Myers Squibb; Dana-Farber Cancer Institute; European Thoracic Oncology Platform; Grupo Espanol Multidisciplinar de Melanoma; Intergroupe Francophone de Cancerologie Thoracique; Ludwig Institute for Cancer Research; Massachusetts General Hospital; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Northwestern University; Olivia Newton-John Cancer Research Institute; Ono Pharmaceutical; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antiretrovirals; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma
  • Phase III Gastric cancer; Glioblastoma; Head and neck cancer; Mesothelioma; Non-small cell lung cancer; Oesophageal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase II Breast cancer; Carcinomatous meningitis; CNS cancer; Colorectal cancer; Gastrointestinal cancer; Gynaecological cancer; Hepatocellular carcinoma; Myelodysplastic syndromes; Neuroendocrine tumours; Ovarian cancer; Pancreatic cancer; Thyroid cancer; Urogenital cancer; Uveal melanoma
  • Phase I/II Liver cancer; Lung cancer; Solid tumours
  • No development reported Lymphoma

Most Recent Events

  • 16 Oct 2017 Updated efficacy data from the phase I/II CheckMate-032 trial in Solid tumours released by Bristol-Myers Squibb
  • 03 Oct 2017 Bristol-Myers Squibb and M.D. Anderson Cancer Center terminates a phase I trial in Multiple Myeloma (Combination therapy; Newly diagnosed) in USA prior to enrolment since it was similar with another study (NCT03283046)
  • 30 Sep 2017 Preregistration for Malignant melanoma (Combination therapy, First-line therapy, Inoperable/Unresectable) in Japan (IV)
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