Ipilimumab

Drug Profile

Ipilimumab

Alternative Names: Anti CTLA-4 monoclonal antibody - Medarex; BMS-734016; MDX-010; MDX-CTLA-4; Yervoy

Latest Information Update: 15 Jun 2017

Price : $50

At a glance

  • Originator Medarex
  • Developer Bavarian Nordic; Bristol-Myers Squibb; Dana-Farber Cancer Institute; European Thoracic Oncology Platform; Grupo Espanol Multidisciplinar de Melanoma; Intergroupe Francophone de Cancerologie Thoracique; Ludwig Institute for Cancer Research; Memorial Sloan-Kettering Cancer Center; Ono Pharmaceutical; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antiretrovirals; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma
  • Phase III Gastric cancer; Glioblastoma; Head and neck cancer; Mesothelioma; Non-small cell lung cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase II Brain metastases; Carcinomatous meningitis; Myelodysplastic syndromes; Oesophageal cancer; Ovarian cancer; Urogenital cancer; Uveal melanoma
  • Phase I/II Adrenal cancer; Colorectal cancer; Liver cancer; Lung cancer; Solid tumours
  • No development reported Lymphoma

Most Recent Events

  • 05 Jun 2017 Efficacy and adverse event data from the phase II MAPS-2 trial in Mesothelioma presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 05 Jun 2017 Bristol-Myers Squibb and Novartis enter into clinical research collaboration for Colorectal cancer
  • 05 Jun 2017 Bristol-Myers Squibb and Novartis plan a phase I/II trial for Colorectal cancer (Combination therapy, Metastatic disease)
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