Imatinib

Drug Profile

Imatinib

Alternative Names: CGP 57148; CGP 57148B; CTI 571; Gleevec; Glivec; Imatinib mesilate; Imatinib mesylate; QTI 571; Ruvise; STI 571

Latest Information Update: 22 Dec 2016

Price : $50

At a glance

  • Originator Novartis
  • Developer Dana-Farber Cancer Institute; Novartis; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antivirals; Benzamides; Piperazines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Bcr-abl tyrosine kinase inhibitors; Platelet-derived growth factor inhibitors; Platelet-derived growth factor receptor antagonists; Proto oncogene protein c-kit inhibitors; Signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Chronic myeloid leukaemia; Dermatofibrosarcoma; Acute lymphoblastic leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute lymphoblastic leukaemia; Chronic myeloid leukaemia; Dermatofibrosarcoma; Gastrointestinal stromal tumours; Hypereosinophilic syndrome; Myelodysplastic syndromes; Systemic mastocytosis
  • Phase II Acute myeloid leukaemia; Fibroma; Non-Hodgkin's lymphoma; Prostate cancer
  • Phase I Mesothelioma
  • No development reported Malignant melanoma
  • Discontinued Diffuse scleroderma; Glioblastoma; Non-small cell lung cancer; Polycythaemia vera; Pulmonary arterial hypertension; Sarcoma; Small cell lung cancer; Systemic scleroderma

Most Recent Events

  • 12 Oct 2016 Discontinued - Phase-II for Diffuse scleroderma in Canada (PO)
  • 15 Mar 2016 Biomarkers information updated
  • 03 Dec 2015 The US FDA approves the first generic of imatinib
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