PEGylated haemoglobin and carbon monoxide

Drug Profile

PEGylated haemoglobin and carbon monoxide

Alternative Names: PEG haemoglobin; PEG haemoglobin carbon monoxide; PEG-bHb-CO; PEG-COHb; PEG-haemoglobin-CO; PEG-Hb; PEG-LEH; Pegylated carboxyhemoglobin bovine; Pegylated haemoglobin carbon monoxide; Polyethylene glycol modified bovine haemoglobin; Sanguinate

Latest Information Update: 31 Jul 2017

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At a glance

  • Originator Enzon Pharmaceuticals; Rutgers
  • Developer Prolong Pharmaceuticals
  • Class Haemoglobins; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Oxygen carriers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Delayed graft function
  • Phase II Cerebral ischaemia; Sickle cell anaemia
  • Phase I Hypoxia
  • Clinical Phase Unknown Beta-thalassaemia

Most Recent Events

  • 22 Jun 2017 Adverse events data from a phase II trial in Sickle cell anaemia presented at the 22nd Congress of the European Haematology Association (EHA-2017)
  • 17 May 2017 Prolong Pharmaceuticals completes a phase-I trial in Anaemia in USA (IV) (NCT02754999)
  • 12 May 2017 Prolong Pharmaceuticals terminates a phase I pharmacokinetic trial according to the results published at the 2017 American Transplant Congress in USA (IV) (NCT02437422)
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