Drug Profile


Alternative Names: CGP 30083; Epoxymexrenone; Inspra; SC 66110; Selara

Latest Information Update: 26 Sep 2017

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At a glance

  • Originator Novartis
  • Developer Medical University of Graz; Pfizer; Solvotrin Innovations
  • Class Antihypertensives; Heart failure therapies; Lactones; Pregnenes; Small molecules
  • Mechanism of Action Aldosterone receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Heart failure; Hypertension
  • Phase III Chronic heart failure; Primary hyperparathyroidism
  • Phase II Left ventricular dysfunction
  • No development reported Postmyocardial infarction

Most Recent Events

  • 01 Nov 2016 Pfizer terminates a phase II/III trial due to futility for Heart failure in Canada (PO) (NCT01708798)
  • 15 Mar 2016 Biomarkers information updated
  • 30 Jun 2015 Medical University of Graz and Pfizer complete a phase III trial in Primary hyperparathyroidism in Austria (ISRCTN33941607)
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