Drug Profile


Alternative Names: Ceoxx; MK 966; Vioxx; Vioxx Acute

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Merck & Co
  • Developer Banyu; CollaGenex Pharmaceuticals; Merck & Co; Merck Frosst
  • Class Antirheumatics; Lactones; Non-opioid analgesics; Sulfones
  • Mechanism of Action Cyclo-oxygenase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.


Highest Development Phases

  • Market Withdrawal Dental pain; Dysmenorrhoea; Musculoskeletal disorders; Osteoarthritis; Pain; Rheumatoid arthritis
  • Discontinued Alzheimer's disease; Colorectal cancer; Familial adenomatous polyposis; Juvenile rheumatoid arthritis; Migraine; Periarthritis; Preterm labour; Sporadic adenomas

Most Recent Events

  • 21 Feb 2005 An advisory committee of the FDA has recommended that the risk-benefit profile for rofecoxib supports marketing in the USA
  • 11 Oct 2004 A clinical study has been added to the adverse events section
  • 01 Oct 2004 Discontinued - Clinical-Phase-Unknown for Juvenile rheumatoid arthritis in Europe (PO)
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