Bortezomib

Drug Profile

Bortezomib

Alternative Names: JNJ-26866138; LDP-341; MG-341; MLN-341; NSC-681239; PS 0341; PS-341; Velcade

Latest Information Update: 19 Jun 2017

Price : $50

At a glance

  • Originator Millennium Pharmaceuticals
  • Developer Dana-Farber Cancer Institute; Duke University; Erasmus MC; Genentech; Hoosier Cancer Research Network; HOVON Foundation; Janssen Pharmaceutical KK; Janssen Research & Development; Janssen-Cilag; Johnson & Johnson; Millennium; Millennium Pharmaceuticals; Singapore General Hospital; Takeda Oncology; Weill Cornell Medical College
  • Class Antineoplastics; Antirheumatics; Boronic acids; Pyrazines; Small molecules
  • Mechanism of Action Apoptosis stimulants; Immunomodulators; Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mantle-cell lymphoma; Multiple myeloma
  • Registered B cell lymphoma
  • Phase III Diffuse large B cell lymphoma
  • Phase II Acute lymphoblastic leukaemia; Glioma; Graft-versus-host disease; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I/II Waldenstrom's macroglobulinaemia
  • Phase I Hodgkin's disease; Malignant melanoma
  • Preregistration Submission Withdrawal Follicular lymphoma
  • No development reported Pancreatic cancer
  • Discontinued Adenocarcinoma; Amyloid light-chain amyloidosis; Cerebral ischaemia; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Non-small cell lung cancer; Prostate cancer; Rheumatoid arthritis; T cell prolymphocytic leukaemia

Most Recent Events

  • 26 Apr 2017 Millennium terminates a phase II trial in Multiple myeloma (Newly diagnosed, Combination therapy) in USA (SC) (IV) (NCT01729338)
  • 01 Feb 2017 Millennium Pharmaceutical completes a phase II trial in Multiple myeloma (First-line therapy, Combination therapy) in USA (IV) (NCT01056276)
  • 18 Jan 2017 M.D. Anderson Cancer Center completes a phase II trial in Myelodysplastic syndromes in USA (SC) (NCT01891968)
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