Bortezomib

Drug Profile

Bortezomib

Alternative Names: JNJ-26866138; LDP-341; MG-341; MLN-341; NSC-681239; PS 0341; PS-341; Velcade

Latest Information Update: 04 Dec 2017

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At a glance

  • Originator Millennium Pharmaceuticals
  • Developer Childrens Mercy Hospital Kansas City; Dana-Farber Cancer Institute; Duke University; Erasmus MC; Genentech; Hoosier Cancer Research Network; HOVON Foundation; Janssen Pharmaceutical KK; Janssen Research & Development; Janssen-Cilag; Johnson & Johnson; Millennium; Millennium Pharmaceuticals; Singapore General Hospital; Takeda Oncology; University of Michigan Comprehensive Cancer Center; Weill Cornell Medical College
  • Class Antineoplastics; Antirheumatics; Boronic acids; Pyrazines; Small molecules
  • Mechanism of Action Apoptosis stimulants; Immunomodulators; Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Mantle-cell lymphoma; Multiple myeloma
  • Registered B cell lymphoma
  • Phase III Diffuse large B cell lymphoma
  • Phase II Acute lymphoblastic leukaemia; Glioma; Graft-versus-host disease; Lymphoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I/II Waldenstrom's macroglobulinaemia
  • Preregistration Submission Withdrawal Follicular lymphoma
  • No development reported Hodgkin's disease; Malignant melanoma; Neuroblastoma; Pancreatic cancer
  • Discontinued Adenocarcinoma; Amyloid light-chain amyloidosis; Cerebral ischaemia; Chronic lymphocytic leukaemia; Chronic myeloid leukaemia; Non-small cell lung cancer; Prostate cancer; Rheumatoid arthritis; T cell prolymphocytic leukaemia

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Diffuse large B cell lymphoma(Combination therapy, Salvage therapy, Second-line therapy or greater) in Singapore (IV, Injection)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Graft-versus-host-disease in USA (SC, Injection)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Graft-versus-host-disease(Combination therapy, Prevention) in USA (IV, Infusion)
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